Publication Highlights

Preprints

Kropp, A., Gillett, D. L., Venugopal, H., Gonzalvez, M. A., Lingford, J. P., Barlow, C. K., ... & Grinter, R. (2024). Quinone extraction drives atmospheric carbon monoxide oxidation in bacteria. bioRxiv, 2024-01.

Munder, F., Voutsinos, M., Hantke, K., Venugopal, H., & Grinter, R. (2024). High-affinity PQQ import is widespread in Gram-negative bacteria. bioRxiv, 2024-06.

Venugopal, H., Mobbs, J., Taveneau, C., Fox, D.R., Vuckovic, Z., Knott, G., Grinter, R., Thal, D.M., Mick, S., Czarnik, C. and Ramm, G., (2024). Obtaining high-resolution cryo-EM structures using a common LaB6, 120-keV electron microscope equipped with a sub 200-keV optimised direct electron detector. bioRxiv, pp.2024-05.

2024

Greening, C., Cabotaje, P. R., Alvarado, L. E. V., Leung, P. M., Land, H., Rodrigues-Oliveira, T., ... Grinter, R., Spang, A., Banfield, J., & Berggren, G. (2024). Minimal and hybrid hydrogenases are active from archaea. Cell, 187(13), 3357-3372.

Fox, D. R., Samuels, I., Binks, S., & Grinter, R. The structure of a haemoglobin–nanobody complex reveals human β‐subunit‐specific interactions. (2024) FEBS letters.

Cottam, C., White, R.T., Beck, L.C., Stewart, C.J., Beatson, S.A., Lowe, E.C., Grinter, R. and Connolly, J.P., (2024). Metabolism of l-arabinose converges with virulence regulation to promote enteric pathogen fitness. Nature Communications, 15(1), p.4462.

Leung, P. M., Grinter, R., Tudor-Matthew, E., Lingford, J. P., Jimenez, L., Lee, H. C., ... & Greening, C. (2024). Trace gas oxidation sustains energy needs of a thermophilic archaeon at suboptimal temperatures. Nature Communications, 15(1), 3219.

2023

Grinter, R., Kropp, A., Venugopal, H., Senger, M., Badley, J., Cabotaje, P. R., ... & Greening, C. (2023). Structural basis for bacterial energy extraction from atmospheric hydrogen. Nature, 615(7952), 541-547.

Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., ...Grinter, R., Kropp, A … & Schwede, T. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics.

Greening, C., Kropp, A., Vincent, K., & Grinter, R. (2023). Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion. Biochemical Society Transactions, 51(5), 1921-1933.

2022

Grinter, R., Kropp, A., Venugopal, H., Senger, M., Badley, J., Cabotaje, P., ... & Greening, C. (2022). Energy extraction from air: structural basis of atmospheric hydrogen oxidation. bioRxiv.

Greening C, and Grinter R. "Microbial oxidation of atmospheric trace gases." Nature Reviews Microbiology (2022): 1-16.

2021

Grinter R, Greening C. Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea. FEMS Microbiology Reviews. 2021;45(5):fuab021.

Grinter R, Morris FC, Dunstan RA, Leung PM, Kropp A, Belousoff M, Gunasinghe SD, Scott NE, Beckham S, Peleg AY, Greening C, Li J, Heinz E, Lithgow T, Levin PA, Rosa PA. BonA from Acinetobacter baumannii Forms a Divisome-Localized Decamer That Supports Outer Envelope Function. mBio. 2021;12(4):e01480-21. doi: doi:10.1128/mBio.01480-21.

Ortiz M, Leung PM, Shelley G, Jirapanjawat T, Nauer PA, Van Goethem MW, Bay SK, Islam ZF, Jordaan K, Vikram S, Chown SL, Hogg ID, Makhalanyane Thulani P, Grinter R, Cowan DA, Greening C. Multiple energy sources and metabolic strategies sustain microbial diversity in Antarctic desert soils. Proceedings of the National Academy of Sciences. 2021;118(45):e2025322118. doi: 10.1073/pnas.2025322118.

Bayly K, Cordero PRF, Kropp A, Huang C, Schittenhelm RB, Grinter R, Greening C, Mycobacteria Tolerate Carbon Monoxide by Remodeling Their Respiratory Chain. mSystems. 2021;6(3):e01292-20. doi: doi:10.1128/mSystems.01292-20.

Bay SK, Dong X, Bradley JA, Leung PM, Grinter R, Jirapanjawat T, Arndt SK, Cook PLM, LaRowe DE, Nauer PA, Chiri E, Greening C. Trace gas oxidizers are widespread and active members of soil microbial communities. Nature Microbiology. 2021;6(2):246-56. doi: 10.1038/s41564-020-00811-w.

2020

Grinter R, Ney B, Brammananth R, Barlow CK, Cordero PR, Gillett DL, Izoré T, Cryle MJ, Harold LK, Cook GM. Cellular and structural basis of synthesis of the unique intermediate dehydro-F420-0 in mycobacteria. Msystems. 2020;5(3).

Rooney WM, Grinter R, Correia A, Parkhill J, Walker DC, Milner JJ. Engineering bacteriocin‐mediated resistance against the plant pathogen Pseudomonas syringae. Plant biotechnology journal. 2020;18(5):1296-306.

Grinter R, Lithgow T. The crystal structure of the TonB-dependent transporter YncD reveals a positively charged substrate-binding site. Acta Crystallographica Section D: Structural Biology. 2020;76(5):484-95.

Hardy JM, Dunstan RA, Grinter R, Belousoff MJ, Wang J, Pickard D, Venugopal H, Dougan G, Lithgow T, Coulibaly F. The architecture and stabilisation of flagellotropic tailed bacteriophages. Nature Communications. 2020;11(1):3748. doi: 10.1038/s41467-020-17505-w.

Järvå MA, Dramicanin M, Lingford JP, Mao R, John A, Jarman KE, Grinter R, Goddard-Borger ED. Structural basis of substrate recognition and catalysis by fucosyltransferase 8. Journal of Biological Chemistry. 2020;295(19):6677-88. doi: 10.1074/jbc.RA120.013291.

Islam ZF, Welsh C, Bayly K, Grinter R, Southam G, Gagen EJ, Greening C. A widely distributed hydrogenase oxidises atmospheric H2 during bacterial growth. The ISME Journal. 2020;14(11):2649-58. doi: 10.1038/s41396-020-0713-4.

2019

Grinter R, Lithgow T. Determination of the molecular basis for coprogen import by Gram-negative bacteria. IUCrJ. 2019;6(3).

Grinter R, Lithgow T. The structure of the bacterial iron-catecholate transporter Fiu suggests that it imports substrates via a two-step mechanism. Journal of Biological Chemistry. 2019;294(51):19523-34. doi: 10.1074/jbc.RA119.011018.

Grinter R, Leung PM, Wijeyewickrema LC, Littler D, Beckham S, Pike RN, Walker D, Greening C, Lithgow T. Protease-associated import systems are widespread in Gram-negative bacteria. PLOS Genetics. 2019;15(10):e1008435. doi: 10.1371/journal.pgen.1008435.

Cordero PR, Grinter R, Hards K, Cryle MJ, Warr CG, Cook GM, Greening C. Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence. Journal of Biological Chemistry. 2019:jbc. RA119. 011076.

2018

Grinter R, Hay ID, Song J, Wang J, Teng D, Dhanesakaran V, Wilksch JJ, Davies MR, Littler D, Beckham SA. FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants. PLoS biology. 2018;16(8):e2006026.

2017

Josts I, Stubenrauch CJ, Vadlamani G, Mosbahi K, Walker D, Lithgow T, Grinter R. The Structure of a Conserved Domain of TamB Reveals a Hydrophobic β Taco Fold. Structure. 2017;25(12):1898-906.e5. doi: https://doi.org/10.1016/j.str.2017.10.002.

2016

Grinter R, Josts I, Mosbahi K, Roszak AW, Cogdell RJ, Bonvin AMJJ, Milner JJ, Kelly SM, Byron O, Smith BO, Walker D. Structure of the bacterial plant-ferredoxin receptor FusA. Nature Communications. 2016;7(1):13308. doi: 10.1038/ncomms13308.

2014

Grinter R, Josts I, Zeth K, Roszak AW, McCaughey LC, Cogdell RJ, Milner JJ, Kelly SM, Byron O, Walker D. Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Molecular microbiology. 2014;93(2):234-46.

McCaughey LC, Grinter R, Josts I, Roszak AW, Waløen KI, Cogdell RJ, Milner J, Evans T, Kelly S, Tucker NP, Byron O, Smith B, Walker D. Lectin-Like Bacteriocins from Pseudomonas spp. Utilise D-Rhamnose Containing Lipopolysaccharide as a Cellular Receptor. PLoS Pathogens. 2014;10(2):e1003898. doi: 10.1371/journal.ppat.1003898.\

2012

Grinter R, Roszak AW, Cogdell RJ, Milner JJ, Walker D. The Crystal Structure of the Lipid II-degrading Bacteriocin Syringacin M Suggests Unexpected Evolutionary Relationships between Colicin M-like Bacteriocins. Journal of Biological Chemistry. 2012;287(46):38876-88.

Grinter R, Milner J, Walker D. Ferredoxin containing bacteriocins suggest a novel mechanism of iron uptake in Pectobacterium spp. PLoS ONE. 2012;7(3):e33033. doi: 10.1371/journal.pone.0033033.